Bioactivity of NANOZR Induced by Alkali TreatmentReport as inadecuate


Bioactivity of NANOZR Induced by Alkali Treatment


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1

Department of Removable Prosthodontics and Occlusion, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121, Japan

2

Department of Periodotology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121, Japan





*

Author to whom correspondence should be addressed.



Academic Editor: Bing Yan

Abstract In recent years, zirconia has been a recognized implant material in clinical dentistry. In the present study, we investigated the performance of an alkali-modified ceria-stabilized tetragonal ZrO2 polycrystalline ceramic-based nanostructured zirconia-alumina composite NANOZR implant by assessing surface morphology and composition, wettability, bovine serum albumin adsorption rate, rat bone marrow RBM cell attachment, and capacity for inducing bone differentiation. NANOZR surfaces without and with alkali treatment served as the control and test groups, respectively. RBM cells were seeded in a microplate with the implant and cultured in osteogenic differentiation medium, and their differentiation was evaluated by measuring alkaline phosphatase ALP activity, osteocalcin OCN production, calcium deposition, and osteogenic gene expression. The alkali-treated NANOZR surface increased ALP activity, OCN production, calcium deposition, and osteogenesis-related gene expression in attached RBM cells. These data suggest that alkali treatment enhances the osteogenesis-inducing capacity of NANOZR implants and may therefore improve their biointegration into alveolar bone. View Full-Text

Keywords: zirconia-alumina nano-composite; bioactivity; alkali treatment zirconia-alumina nano-composite; bioactivity; alkali treatment





Author: Mariko Nishizaki 1,* , Satoshi Komasa 1, Yoichiro Taguchi 2, Hiroshi Nishizaki 1 and Joji Okazaki 1

Source: http://mdpi.com/



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