ADAR1 and MicroRNA; A Hidden Crosstalk in CancerReport as inadecuate


ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer


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1

Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea

2

Department of Gastroenterology and Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea





*

Author to whom correspondence should be addressed.



Academic Editor: Kumiko Ui-Tei

Abstract The evolution of cancer cells is believed to be dependent on genetic or epigenetic alterations. However, this concept has recently been challenged by another mode of nucleotide alteration, RNA editing, which is frequently up-regulated in cancer. RNA editing is a biochemical process in which either Adenosine or Cytosine is deaminated by a group of RNA editing enzymes including ADAR Adenosine deaminase; RNA specific or APOBEC3B Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3B. The result of RNA editing is usually adenosine to inosine A-to-I or cytidine to uridine C-to-U transition, which can affect protein coding, RNA stability, splicing and microRNA-target interactions. The functional impact of these alterations is largely unclear and is a subject of extensive research. In the present review, we will specifically focus on the influence of ADARs on carcinogenesis via the regulation of microRNA processing and functioning. This follows a brief review of the current knowledge of properties of ADAR enzyme, RNA editing, and microRNA processing. View Full-Text

Keywords: ADAR Adenosine deaminase; RNA specific; UTR untranslated region; NGS Next Generation Sequencing ADAR Adenosine deaminase; RNA specific; UTR untranslated region; NGS Next Generation Sequencing





Author: Charles J. Cho 1, Seung-Jae Myung 2 and Suhwan Chang 1,*

Source: http://mdpi.com/



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