Advances in Identifying Beryllium Sensitization and DiseaseReport as inadecuate




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1

Division of Health Studies, Agency for Toxic Substances and Disease Registry, CDC Chamblee Campus, Building 106, 4770 Buford Highway NE Mail Stop F-57, Atlanta, GA 30341, USA

2

Division of Health Assessment and Consultation, Agency for Toxic Substances and Disease Registry, CDC Chamblee Campus, Building 106, 4770 Buford Highway NE Mail Stop F-59, Atlanta, GA 30341, USA





*

Author to whom correspondence should be addressed.



Abstract Beryllium is a lightweight metal with unique qualities related to stiffness, corrosion resistance, and conductivity. While there are many useful applications, researchers in the 1930s and l940s linked beryllium exposure to a progressive occupational lung disease. Acute beryllium disease is a pulmonary irritant response to high exposure levels, whereas chronic beryllium disease CBD typically results from a hypersensitivity response to lower exposure levels. A blood test, the beryllium lymphocyte proliferation test BeLPT, was an important advance in identifying individuals who are sensitized to beryllium BeS and thus at risk for developing CBD. While there is no true -gold standard- for BeS, basic epidemiologic concepts have been used to advance our understanding of the different screening algorithms. View Full-Text

Keywords: beryllium; BeLPT; beryllium sensitization; BeS; screening; chronic beryllium disease; CBD beryllium; BeLPT; beryllium sensitization; BeS; screening; chronic beryllium disease; CBD





Author: Dan Middleton 1,* and Peter Kowalski 2

Source: http://mdpi.com/



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