Potential Risk Factors for Cutaneous Squamous Cell Carcinoma include Oral Contraceptives: Results of a Nested Case-Control StudyReport as inadecuate




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1

Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA

2

Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA

3

Center for Health of Vulnerable Populations, Office of the Dean, School of Nursing, University of North Carolina, Greensboro, NC 27402, USA

4

Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA





*

Author to whom correspondence should be addressed.



Abstract Recently, a population-based case-control study observed a 60% increased odds ratio OR for cutaneous squamous cell carcinoma SCC among women who had ever used oral contraceptives OCs compared with non users 95% confidence interval CI = 1.0–2.5. To further characterize the putative association between OC use and SCC risk, we conducted a nested case-control study using a large retrospective cohort of 111,521 Kaiser Permanente Northern California members. Multivariable conditional logistic regression was used to estimate ORs and CIs adjusting for known and hypothesized SCC risk factors. Pre-diagnostic OC use was associated with a statistically significant increased OR for SCC in univariate analysis OR = 2.4, CI = 1.2–4.8, with borderline statistical significance in multivariable analysis CI = 2.0, CI = 0.91–4.5. Given the high incidence of SCC in the general population and the prevalent use of OCs among women in the United States, there is a need for more large, carefully designed epidemiologic studies to determine whether the observed association between OC use and SCC can be replicated and to better understand the etiologic basis of an association if one exists. View Full-Text

Keywords: squamous cell carcinoma; oral contraceptives; risk factors; epidemiology squamous cell carcinoma; oral contraceptives; risk factors; epidemiology





Author: Maryam M. Asgari 1,2, Jimmy T. Efird 3,* , E. Margaret Warton 1 and Gary D. Friedman 1,4

Source: http://mdpi.com/



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