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University Institute of Social and Preventive Medicine, Rue du Bugnon 17, 1005 Lausanne, Switzerland





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Abstract Mendelian randomization refers to the random allocation of alleles at the time of gamete formation. In observational epidemiology, this refers to the use of genetic variants to estimate a causal effect between a modifiable risk factor and an outcome of interest. In this review, we recall the principles of a -Mendelian randomization- approach in observational epidemiology, which is based on the technique of instrumental variables; we provide simulations and an example based on real data to demonstrate its implications; we present the results of a systematic search on original articles having used this approach; and we discuss some limitations of this approach in view of what has been found so far. View Full-Text

Keywords: genetic epidemiology; causality; observational studies; instrumental variables genetic epidemiology; causality; observational studies; instrumental variables





Author: Murielle Bochud * and Valentin Rousson

Source: http://mdpi.com/



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