Differences of Urinary Arsenic Metabolites and Methylation Capacity between Individuals with and without Skin Lesions in Inner Mongolia, Northern ChinaReport as inadecuate




Differences of Urinary Arsenic Metabolites and Methylation Capacity between Individuals with and without Skin Lesions in Inner Mongolia, Northern China - Download this document for free, or read online. Document in PDF available to download.

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Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, No. 22, Qi Xiang Tai Road, Heping District, Tianjin 300070, China

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Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, No. 92, Bei Er Road, Heping District, Shenyang 110001, China

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Library of Tianjin Medical University, Tianjin Medical University, No. 22, Qi Xiang Tai Road, Heping District, Tianjin 300070, China





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Abstract Incomplete arsenic As methylation has been considered a risk factor of As-related diseases. This study aimed to examine the difference of urinary As metabolites and the methylation capacity between subjects with and without skin lesions. Urinary inorganic arsenic iAs, monomethylarsonic acid MMA, and dimethylarsinic acid DMA were analyzed. The percentage of each As species iAs%, MMA%, and DMA%, the primary methylation index PMI and secondary methylation index SMI were calculated. The results showed that subjects with skin lesions have higher levels of urinary iAs 99.08 vs. 70.63 μg-g Cr, p = 0.006 and MMA 69.34 vs. 42.85 μg-g Cr, p = 0.016 than subjects without skin lesions after adjustment for several confounders. Significant differences of urianry MMA% 15.49 vs. 12.11, p = 0.036 and SMI 0.74 vs. 0.81, p = 0.025 were found between the two groups. The findings of the present study suggest that subjects with skin lesions may have a lower As methylation capacity than subjects without skin lesions. View Full-Text

Keywords: arsenic; groundwater; skin lesion; methylation capacity; metabolism arsenic; groundwater; skin lesion; methylation capacity; metabolism





Author: Qiang Zhang 1, Yongfang Li 2, Juan Liu 3, Da Wang 2, Quanmei Zheng 2 and Guifan Sun 2,*

Source: http://mdpi.com/



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