Parasitic Manipulation of Host Behaviour: Baculovirus SeMNPV EGT Facilitates Tree-Top Disease in Spodoptera exigua Larvae by Extending the Time to DeathReport as inadecuate




Parasitic Manipulation of Host Behaviour: Baculovirus SeMNPV EGT Facilitates Tree-Top Disease in Spodoptera exigua Larvae by Extending the Time to Death - Download this document for free, or read online. Document in PDF available to download.

1

Laboratory of Virology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, the Netherlands

2

Centre for Ecology and Conservation, Biosciences, University of Exeter, Penryn, Cornwall TR10 9FE, UK





*

Author to whom correspondence should be addressed.



Academic Editors: Kenneth Wilson, Fleur Ponton and Sheena Cotter

Abstract Many parasites enhance their dispersal and transmission by manipulating host behaviour. One intriguing example concerns baculoviruses that induce hyperactivity and tree-top disease i.e., climbing to elevated positions prior to death in their caterpillar hosts. Little is known about the underlying mechanisms of such parasite-induced behavioural changes. Here, we studied the role of the ecdysteroid UDP-glucosyltransferase egt gene of Spodoptera exigua multiple nucleopolyhedrovirus SeMNPV in tree-top disease in S. exigua larvae. Larvae infected with a mutant virus lacking the egt gene exhibited a shorter time to death and died before the induction of tree-top disease. Moreover, deletion of either the open reading frame or the ATG start codon of the egt gene prevented tree-top disease, indicating that the EGT protein is involved in this process. We hypothesize that SeMNPV EGT facilitates tree-top disease in S. exigua larvae by prolonging the larval time to death. Additionally, we discuss the role of egt in baculovirus-induced tree-top disease. View Full-Text

Keywords: behavioural manipulation; baculovirus; tree-top disease; SeMNPV; egt gene; Spodoptera exigua behavioural manipulation; baculovirus; tree-top disease; SeMNPV; egt gene; Spodoptera exigua





Author: Yue Han 1, Stineke van Houte 1,2, Gerben F. Drees 1, Monique M. van Oers 1,* and Vera I. D. Ros 1

Source: http://mdpi.com/



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