Current Controversies on the Pathogenesis of Medication-Related Osteonecrosis of the JawReport as inadecuate


Current Controversies on the Pathogenesis of Medication-Related Osteonecrosis of the Jaw


Current Controversies on the Pathogenesis of Medication-Related Osteonecrosis of the Jaw - Download this document for free, or read online. Document in PDF available to download.

Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China





Academic Editor: Christian Walter

Abstract Medication-related osteonecrosis of the jaw MRONJ was first reported more than a decade ago. Since then, numerous cases have been diagnosed. Currently, there are three groups of drugs related to MRONJ: bisphosphonates, denosumab and anti-angiogenic drugs. As MRONJ can lead to debilitating clinical sequels and limited effective treatment options are available, much research has been done in understanding its pathophysiology. Until now, the exact pathogenesis of MRONJ has not been fully elucidated. While history of invasive dental procedures or local trauma may be present, some cases occur spontaneously without any preceding factors. This review aims to examine and discuss the three main hypotheses for the pathogenesis of MRONJ, namely suppressed bone turnover, cellular toxicity and infection. View Full-Text

Keywords: osteonecrosis of the jaw; BRONJ; MRONJ; DRONJ; bisphosphonate; zoledronate; denosumab; anti-angiogenic osteonecrosis of the jaw; BRONJ; MRONJ; DRONJ; bisphosphonate; zoledronate; denosumab; anti-angiogenic





Author: Winnie Zee Man Wat

Source: http://mdpi.com/



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