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1

Department of Computer Science, University of York, Heslington, York, YO10 5GH, UK

2

York Computational Immunology Laboratory, University of York, Heslington, York, YO10 5DD, UK

3

Department of Management Science, Lancaster University Management School, Lancaster, LA1 4YX, UK

4

Department of Electronics, University of York, Heslington, York, YO10 5DD, UK

5

Department of Cardiovascular Science, Sheffield University Medical School, Sheffield, S10 2RX, UK





*

Author to whom correspondence should be addressed.



Abstract In this review article, we discuss the current state of computational modelling of the nuclear factor-kappa B NF-ΚB signalling pathway. NF-ΚB is a transcription factor, which is ubiquitous within cells and controls a number of immune responses, including inflammation and apoptosis. The NF-ΚB signalling pathway is tightly regulated, commencing with activation at the cell membrane, signal transduction through various components within the cytoplasm, translocation of NF-ΚB into the nucleus and, finally, the transcription of various genes relating to the innate and adaptive immune responses. There have been a number of computational mathematical models developed of the signalling pathway over the past decade. This review describes how these approaches have helped advance our understanding of NF-ΚB control. View Full-Text

Keywords: NF-KB; computational biology; agent-based modelling; mathematical modelling; systems biology; signal transduction NF-KB; computational biology; agent-based modelling; mathematical modelling; systems biology; signal transduction





Author: Richard A. Williams 1,2,3,* , Jon Timmis 2,4 and Eva E. Qwarnstrom 5

Source: http://mdpi.com/



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