Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic ResponseReport as inadecuate


Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response


Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response - Download this document for free, or read online. Document in PDF available to download.

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA





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Academic Editors: Deric L. Wheeler and Toni M. Brand

Abstract The TAM family of receptors i.e., Tyro3, Axl, and Mertk, and their ligands Growth arrest specific factor 6 Gas6 and Protein S Pros1 contribute to several oncogenic processes, such as cell survival, invasion, migration, chemo-resistance, and metastasis, whereby expression often correlates with poor clinical outcomes. In recent years, there has been great interest in the study of TAM receptors in cancer, stemming both from their roles as oncogenic signaling receptors, as well as their roles in tumor immunology. As a result, several classes of TAM inhibitors that include small molecule tyrosine kinase inhibitors, monoclonal antibodies, decoy receptors, as well as novel strategies to target TAM ligands are being developed. This paper will review the biology of TAM receptors and their ligands with a focus on cancer, as well as evidence-based data for the continued pursuit of TAM-Gas6 inhibitors in clinical practice. View Full-Text

Keywords: Tyro3; Axl; Mertk; Gas6; protein S; immune evasion; tumor microenvironment Tyro3; Axl; Mertk; Gas6; protein S; immune evasion; tumor microenvironment





Author: Viralkumar Davra, Stanley G. Kimani, David Calianese and Raymond B. Birge *

Source: http://mdpi.com/



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