Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding CancerReport as inadecuate


Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer


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1

Division of Science, Yale-NUS College, Singapore 138527, Singapore

2

Department of Biological Science, National University of Singapore, Singapore 138615, Singapore





*

Author to whom correspondence should be addressed.



Academic Editor: Zhixiang Wang

Abstract EGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental pathway regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for the EGF pathway in Drosophila embryogenesis. We review the existing body of evidence concerning EGF signaling in Drosophila embryogenesis focusing on current uncertainties in the field and areas for future study. This review provides a foundation for utilizing the Drosophila model system for research into EGF effects on cancer. View Full-Text

Keywords: EGF signaling; Drosophila development; RAS; RAF; MAP kinase; MEK EGF signaling; Drosophila development; RAS; RAF; MAP kinase; MEK





Author: Jay B. Lusk 1, Vanessa Y. M. Lam 1 and Nicholas S. Tolwinski 1,2,*

Source: http://mdpi.com/



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