The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple MyelomaReport as inadecuate


The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma


The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma - Download this document for free, or read online. Document in PDF available to download.

1

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7UQ, UK

2

Department of Haematology, Norfolk and Norwich University Hospitals National Health Service Trust, Norwich NR4 7UY, UK





*

Author to whom correspondence should be addressed.



Academic Editor: Marco Falasca

Abstract Despite the development of novel treatments in the past 15 years, many blood cancers still remain ultimately fatal and difficult to treat, particularly acute myeloid leukaemia AML and multiple myeloma MM. While significant progress has been made characterising small-scale genetic mutations and larger-scale chromosomal translocations that contribute to the development of various blood cancers, less is understood about the complex microenvironment of the bone marrow BM, which is known to be a key player in the pathogenesis of chronic lymphocytic leukaemia CLL, AML and MM. This niche acts as a sanctuary for the cancerous cells, protecting them from chemotherapeutics and encouraging clonal cell survival. It does this by upregulating a plethora of signalling cascades within the malignant cell, with the phosphatidylinositol-3-kinase PI3K pathway taking a critical role. This review will focus on how the PI3K pathway influences disease progression and the individualised role of the PI3K subunits. We will also summarise the current clinical trials for PI3K inhibitors and how these trials impact the treatment of blood cancers. View Full-Text

Keywords: AML; myeloma; microenvironment; PI3K AML; myeloma; microenvironment; PI3K





Author: Rachel E. Piddock 1, Kristian M. Bowles 1,2 and Stuart A. Rushworth 1,*

Source: http://mdpi.com/



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