PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney CystsReport as inadecuate




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1

Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino 10126, Italy

2

Department of Public Health and Pediatrics, University of Torino, Torino 10126, Italy



These authors equally contributed to this work.





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Author to whom correspondence should be addressed.



Academic Editor: Marco Falasca

Abstract The members of the PhosphoInositide-3 Kinase PI3K protein family are well-known regulators of proliferative signals. By the generation of lipid second messengers, they mediate the activation of AKT-PKB AKT and mammalian Target Of Rapamycin mTOR pathways. Although mutations in the PI3K-AKT-mTOR pathway are highly characterized in cancer, recent evidence indicates that alterations in the proliferative signals are major drivers of other diseases such as overgrowth disorders and polycystic kidney disease. In this review, we briefly summarize the role of the PI3K-AKT-mTOR pathway in cell proliferation by comparing the effect of alterations in PI3K enzymes in different tissues. In particular, we discuss the most recent findings on how the same pathway may lead to different biological effects, due to the convergence and cooperation of different signaling cascades. View Full-Text

Keywords: PI3K; mTOR; proliferation; overgrowth syndrome; polycystic kidney disease PI3K; mTOR; proliferation; overgrowth syndrome; polycystic kidney disease





Author: Maria Chiara De Santis 1,†, Valentina Sala 1,†, Miriam Martini 1, Giovanni Battista Ferrero 2 and Emilio Hirsch 1,*

Source: http://mdpi.com/



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