Is Polysialylated NCAM Not Only a Regulator during Brain Development But also during the Formation of Other OrgansReport as inadecuate


Is Polysialylated NCAM Not Only a Regulator during Brain Development But also during the Formation of Other Organs


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1

Department of Reproductive Biology, Leibniz Institute for Farm Animal Biology FBN, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

2

ITech Progress GmbH, Donnersbergweg 4, 67059 Ludwigshafen, Germany





*

Author to whom correspondence should be addressed.



Academic Editor: Jukka Finne

Abstract In mammals several cell adhesion molecules are involved during the pre- and postnatal development of all organ systems. A very prominent member of this family is the neural cell adhesion molecule NCAM. Interestingly, NCAM can be a target for a special form of posttranslational modification: polysialylation. Whereas nearly all extracellular proteins bear mono-sialic acid residues, only a very small group can be polysialylated. Polysialic acid is a highly negatively-charged sugar polymer and can comprise more than 90 sialic acid residues in postnatal mouse brains increasing dramatically the hydrodynamic radius of their carriers. Thus, adhesion and communication processes on cell surfaces are strongly influenced allowing, e.g., the migration of neuronal progenitor cells. In the developing brain the essential role of polysialylated NCAM has been demonstrated in many studies. In comparison to the neuronal system, however, during the formation of other organs the impact of the polysialylated form of NCAM is not well characterized and the number of studies is limited so far. This review summarizes these observations and discusses possible roles of polysialylated NCAM during the development of organs other than the brain. View Full-Text

Keywords: polysialic acid; NCAM; sialic acids; cell adhesion molecule; organogenesis; pre- and postnatal development polysialic acid; NCAM; sialic acids; cell adhesion molecule; organogenesis; pre- and postnatal development





Author: Christina E. Galuska 1, Thomas Lütteke 2 and Sebastian P. Galuska 1,*

Source: http://mdpi.com/



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