Fabrication of Bioactive Surfaces by Functionalization of Electroactive and Surface-Active Block CopolymersReport as inadecuate


Fabrication of Bioactive Surfaces by Functionalization of Electroactive and Surface-Active Block Copolymers


Fabrication of Bioactive Surfaces by Functionalization of Electroactive and Surface-Active Block Copolymers - Download this document for free, or read online. Document in PDF available to download.

1

Center for Functional Nanoscale Materials and Department of Chemistry, Clark Atlanta University, Atlanta, GA 30314, USA

2

Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA

3

Department of Physics, Clark Atlanta University, Atlanta, GA 30314, USA



These authors contributed equally to this work.





*

Authors to whom correspondence should be addressed.



Abstract Biofunctional block copolymers are becoming increasingly attractive materials as active components in biosensors and other nanoscale electronic devices. We have described two different classes of block copolymers with biofuctional properties. Biofunctionality for block copolymers is achieved through functionalization with appropriate biospecific ligands. We have synthesized block copolymers of electroactive poly3-decylthiophene and 2-hydroxyethyl methacrylate by atom transfer radical polymerization. The block copolymers were functionalized with the dinitrophenyl DNP groups, which are capable of binding to Immunoglobulin E IgE on cell surfaces. The block copolymers were shown to be redox active. Additionally, the triblock copolymer of α, ω-bi-biotin polyethylene oxide-b-poly styrene-b-polyethylene oxide was also synthesized to study their capacity to bind fluorescently tagged avidin. The surface-active property of the polyethylene oxide block improved the availability of the biotin functional groups on the polymer surfaces. Fluorescence microscopy observations confirm the specific binding of biotin with avidin. View Full-Text

Keywords: block copolymers; biosensor; ionic polymerization; atom transfer radical polymerization; fluorescence microscope block copolymers; biosensor; ionic polymerization; atom transfer radical polymerization; fluorescence microscope





Author: Omotunde Olubi 1,†, Laurisa London 1,†, Biswajit Sannigrahi 1,* , Peri Nagappan 2, Michael Williams 3 and Ishrat M. Khan 1,*

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents