Potential and Prospects of Continuous Polyhydroxyalkanoate PHA ProductionReport as inadecuate


Potential and Prospects of Continuous Polyhydroxyalkanoate PHA Production


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1

Office of Research Management and Service, c-o Institute of Chemistry, Research Group Interfaces, Division of Physical and Theoretical Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28-III, Graz A-8010, Austria

2

ARENA-Association for Resource Efficient and Sustainable Technologies, Inffeldgasse 21b, Graz 8010, Austria





*

Author to whom correspondence should be addressed.



Academic Editor: Anthony Guiseppi-Elie

Abstract Together with other so-called -bio-plastics-, Polyhydroxyalkanoates PHAs are expected to soon replace established polymers on the plastic market. As a prerequisite, optimized process design is needed to make PHAs attractive in terms of costs and quality. Nowadays, large-scale PHA production relies on discontinuous fed-batch cultivation in huge bioreactors. Such processes presuppose numerous shortcomings such as nonproductive time for reactor revamping, irregular product quality, limited possibility for supply of certain carbon substrates, and, most of all, insufficient productivity. Therefore, single- and multistage continuous PHA biosynthesis is increasingly investigated for production of different types of microbial PHAs; this goes for rather crystalline, thermoplastic PHA homopolyesters as well as for highly flexible PHA copolyesters, and even blocky-structured PHAs consisting of alternating soft and hard segments. Apart from enhanced productivity and constant product quality, chemostat processes can be used to elucidate kinetics of cell growth and PHA formation under constant process conditions. Furthermore, continuous enrichment processes constitute a tool to isolate novel powerful PHA-producing microbial strains adapted to special environmental conditions. The article discusses challenges, potential and case studies for continuous PHA production, and shows up new strategies to further enhance such processes economically by developing unsterile open continuous processes combined with the application of inexpensive carbon feedstocks. View Full-Text

Keywords: bioreactor cascade; chemostat; continuous process; copolyester; extremophiles; inexpensive carbon sources; polyhydroxyalkanoates PHA; process design; unsterile process bioreactor cascade; chemostat; continuous process; copolyester; extremophiles; inexpensive carbon sources; polyhydroxyalkanoates PHA; process design; unsterile process





Author: Martin Koller 1,2,* and Gerhart Braunegg 2

Source: http://mdpi.com/



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