Na-K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative StressReport as inadecuate


Na-K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress


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1

Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA

2

Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA





*

Author to whom correspondence should be addressed.



Academic Editor: Dewan S. A. Majid

Abstract Other than genetic regulation of salt sensitivity of blood pressure, many factors have been shown to regulate renal sodium handling which contributes to long-term blood pressure regulation and have been extensively reviewed. Here we present our progress on the Na-K-ATPase signaling mediated sodium reabsorption in renal proximal tubules, from cardiotonic steroids-mediated to reactive oxygen species ROS-mediated Na-K-ATPase signaling that contributes to experimental salt sensitivity. View Full-Text

Keywords: Na-K-ATPase; signaling; cardiotonic steroids; ROS; renal sodium handling; salt sensitivity Na-K-ATPase; signaling; cardiotonic steroids; ROS; renal sodium handling; salt sensitivity





Author: Jiang Liu 1,* , Yanling Yan 1, Ying Nie 1 and Joseph I. Shapiro 2

Source: http://mdpi.com/



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