Antioxidant Properties of Selenophene, Thiophene and Their Aminocarbonitrile DerivativesReport as inadecuate


Antioxidant Properties of Selenophene, Thiophene and Their Aminocarbonitrile Derivatives


Antioxidant Properties of Selenophene, Thiophene and Their Aminocarbonitrile Derivatives - Download this document for free, or read online. Document in PDF available to download.

Aram Bagrat Nalbandyan Institute of Chemical Physics, National Academy of Sciences, 5-2 Sevak Street, Yerevan 0014, Armenia





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Academic Editors: Xin Gen Lei and Wen-Hsing Cheng

Abstract The oxygen radical absorbance capacity ORAC method was used to detect the antiperoxyradical ability of organoselenium compounds: selenophene and its derivative, 2-amino-4,5,6,7-tetrahydro-1-selenophene-3-carbonitrile ATSe; while as a comparison, the sulfur-containing analogue of selenophene—thiophene and its derivative—2-amino-4,5,6,7-tetrahydro-1-thiophene-3-carbonitrile ATS—was selected. Cyclic voltammetry CV, differential pulse voltammetry DPV and squarewave voltammetry SWV methods were used to determine the redox characteristics of organoselenium and organosulfur compounds. The antiradical activity and capacity of the studied compounds were also measured by using stable radical 2,2ʹ-diphenyl-1-picrylhydrazyl DPPH. Detected anodic peaks of the oxidation of selenophene, thiophene and their derivatives in CV, DPV and SWV in the interval of −1200 ÷ +1600 mV potentials in regard to the Ag-Ag+ medium of acetonitrile prove the presence of antiperoxyradical activity in regard to oxidizers, i.e., peroxyradicals. The chemical mechanism of the antiperoxyradical ability of selenophene, thiophene and their organic derivatives is proposed. View Full-Text

Keywords: selenophene; thiophene; aminocarbonitrile derivatives; antioxidant; antiperoxyradical capacity; CV; DPV and SWV voltammetry selenophene; thiophene; aminocarbonitrile derivatives; antioxidant; antiperoxyradical capacity; CV; DPV and SWV voltammetry





Author: Levon A. Tavadyan * , Zaruhi H. Manukyan, Lusik H. Harutyunyan, Makich V. Musayelyan, Adrine D. Sahakyan and Hakob G. Tonikyan

Source: http://mdpi.com/



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