Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future ChallengesReport as inadecuate


Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges


Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges - Download this document for free, or read online. Document in PDF available to download.

1

Department of Medicine and Surgery, University of Parma, Via Gramsci 14, Parma 43126, Italy

2

Centre for Molecular and Translational Oncology COMT, University of Parma, Parco Area delle Scienze 11-a, Parma 43124, Italy

3

National Institute of Biostructure and Biosystems INBB, Viale Medaglie d’Oro 305, Rome 00136, Italy

4

Fondazione Umberto Veronesi, Piazza Velasca 5, Milan 20122, Italy





*

Authors to whom correspondence should be addressed.



Academic Editor: H.P. Vasantha Rupasinghe

Abstract Green tea catechins GTCs are a family of chemically related compounds usually classified as antioxidant molecules. Epidemiological evidences, supported by interventional studies, highlighted a more than promising role for GTCs in human prostate cancer PCa chemoprevention. In the last decades, many efforts have been made to gain new insights into the mechanism of action of GTCs. Now it is clear that GTCs’ anticancer action can no longer be simplistically limited to their direct antioxidant-pro-oxidant properties. Recent contributions to the advancement of knowledge in this field have shown that GTCs specifically interact with cellular targets, including cell surface receptors, lipid rafts, and endoplasmic reticulum, modulate gene expression through direct effect on transcription factors or indirect epigenetic mechanisms, and interfere with intracellular proteostasis at various levels. Many of the effects observed in vitro are dose and cell context dependent and take place at concentrations that cannot be achieved in vivo. Poor intestinal absorption together with an extensive systemic and enteric metabolism influence GTCs’ bioavailability through still poorly understood mechanisms. Recent efforts to develop delivery systems that increase GTCs’ overall bioavailability, by means of biopolymeric nanoparticles, represent the main way to translate preclinical results in a real clinical scenario for PCa chemoprevention. View Full-Text

Keywords: green tea catechins; prostate cancer; chemoprevention; nanochemoprevention; antioxidant; mechanism of action green tea catechins; prostate cancer; chemoprevention; nanochemoprevention; antioxidant; mechanism of action





Author: Valeria Naponelli 1,2,3,4, Ileana Ramazzina 1,2,3, Chiara Lenzi 1, Saverio Bettuzzi 1,2,3,* and Federica Rizzi 1,2,3,*

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents