Vol 70: Z-5-3,4,5-Tri-meth-oxy-styr-yl-2,3-di-hydro-thieno3,4-b1,4dioxine.Report as inadecuate

 Vol 70: Z-5-3,4,5-Tri-meth-oxy-styr-yl-2,3-di-hydro-thieno3,4-b1,4dioxine.

Vol 70: Z-5-3,4,5-Tri-meth-oxy-styr-yl-2,3-di-hydro-thieno3,4-b1,4dioxine. - Download this document for free, or read online. Document in PDF available to download.

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This article is from Acta Crystallographica Section E: Structure Reports Online, volume 70.AbstractIn the title compound, C17H18O5S, an analogue of the potent anti­cancer agent combretastatin A-4, the alkene C=C bond has a cis conformation and the C—C=C—C torsion angle is 9.0 3°. The dihedral angle between the benzene and thio­phene rings is 54.07 4°. The dioxene ring adopts a half-chair conformation, with the C atoms of the methyl­ene groups displaced by −0.325 2 and 0.341 3 Å from the plane of the other atoms. The C atoms of the two meta-meth­oxy groups are close to being coplanar with their attached benzene ring displacements = −0.025 2 and −0.196 2 Å, whereas the C atom of the para-meth­oxy group is significantly displaced by −1.107 2 Å. In the crystal, C—H⋯O hydrogen bonds link the mol­ecules into 0-11 chains, which feature two different types of R226 loops.

Author: Liu, Yu-Tao; Chu, Gang

Source: https://archive.org/


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