Vol 36: Various Oscillation Patterns of Serum Fibroblast Growth Factor 21 Concentrations in Healthy Volunteers.Report as inadecuate



 Vol 36: Various Oscillation Patterns of Serum Fibroblast Growth Factor 21 Concentrations in Healthy Volunteers.


Vol 36: Various Oscillation Patterns of Serum Fibroblast Growth Factor 21 Concentrations in Healthy Volunteers. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 36: Various Oscillation Patterns of Serum Fibroblast Growth Factor 21 Concentrations in Healthy Volunteers.
This article is from Diabetes & Metabolism Journal, volume 36.AbstractBackground: Fibroblast growth factor 21 FGF21 was originally identified as a paroxysm proliferator activated receptor-α target gene product and is a hormone involved in metabolic regulation. The purpose of this study was to investigate the diurnal variation of serum FGF21 concentration in obese and non-obese healthy volunteers. Methods: Blood samples were collected from five non-obese body mass index BMI ≤23 kg-m2 and five obese BMI ≥25 kg-m2 healthy young men every 30 to 60 minutes over 24 hours. Serum FGF21 concentrations were determined by radioimmunoassay. Anthropometric parameters, glucose, free fatty acid, insulin, leptin, and cortisol concentrations were also measured. Results: The serum FGF21 concentrations displayed various individual oscillation patterns. The oscillation frequency ranged between 6 and 12 times per day. The average duration of oscillation was 2.52 hours range, 1.9 to 3.0 hours. The peaks and troughs of FGF21 oscillation showed no circadian rhythm. However, the oscillation frequency had a diurnal variation and was lower during the light-off period than during the light-on period 2.4 vs. 7.3 times, P



Author: Lee, Sang Ah; Jeong, Eunheiu; Kim, Eun Hee; Shin, Mi-Seon; Hwang, Jenie Yoonoo; Koh, Eun Hee; Lee, Woo Je; Park, Joong-Yeol; Kim, Min-Seon

Source: https://archive.org/



DOWNLOAD PDF




Related documents