Vol 13: Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study Supplementary Cholecalciferol in recovery from tuberculosis. A randomized, placebo-controlled, clinical trial of vitamin D supplemeReport as inadecuate



 Vol 13: Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study Supplementary Cholecalciferol in recovery from tuberculosis. A randomized, placebo-controlled, clinical trial of vitamin D suppleme


Vol 13: Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study Supplementary Cholecalciferol in recovery from tuberculosis. A randomized, placebo-controlled, clinical trial of vitamin D suppleme - Download this document for free, or read online. Document in PDF available to download.

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This article is from BMC Infectious Diseases, volume 13.AbstractBackground: Vitamin D enhances host protective immune responses to Mycobacterium tuberculosis by suppressing Interferon-gamma IFN-g and reducing disease associated inflammation in the host. The objectives of this study were to determine whether vitamin D supplementation to patients with tuberculosis TB could influence recovery. Methods: Two hundred and fifty nine patients with pulmonary TB were randomized to receive either 600,000 IU of Intramuscular vitamin D3 or placebo for 2 doses. Assessments were performed at 4, 8 and 12 weeks. Early secreted and T cell activated 6 kDa ESAT6 and Mycobacterium tuberculosis sonicate MTBs antigen induced whole blood stimulated IFN-g responses were measured at 0 and 12 weeks. Statistical comparisons between outcome variables at 0 and 12 weeks were performed using Student’s t-test and Chi2 tests. Results: After 12 weeks, the vitamin D supplemented arm demonstrated significantly greater mean weight gain kg + 3.75, 3.16 – 4.34 versus + 2.61 95% CI 1.99 – 3.23 p 0.009 and lesser residual disease by chest radiograph; number of zones involved 1.35 v-s 1.82 p 0.004 95% CI 0.15, 0.79 and 50% or greater reduction in cavity size 106 89.8% v-s 111 94.8%, p 0.035. Vitamin D supplementation led to significant increase in MTBs-induced IFN-g secretion in patients with baseline ‘Deficient’ 25-hydroxyvitamin D serum levels p 0.021. Conclusions: Supplementation with high doses of vitamin D accelerated clinical, radiographic improvement in all TB patients and increased host immune activation in patients with baseline ‘Deficient’ serum vitamin D levels. These results suggest a therapeutic role for vitamin D in the treatment of TB. Trial registration: ClinicalTrials.gov; No. NCT01130311; URL: clinicaltrials.gov



Author: Salahuddin, Nawal; Ali, Farheen; Hasan, Zahra; Rao, Nisar; Aqeel, Masooma; Mahmood, Faisal

Source: https://archive.org/



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