Vol 2: Vitamin D receptor and megalin gene polymorphisms are associated with central adiposity status and changes among US adults.Report as inadecuate



 Vol 2: Vitamin D receptor and megalin gene polymorphisms are associated with central adiposity status and changes among US adults.


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This article is from Journal of Nutritional Science, volume 2.AbstractWe examined longitudinal associations of vitamin D receptor VDR and megalin LRP2; LDL receptor-related protein-2 gene polymorphisms with central adiposity. We used data from the Baltimore Longitudinal Study of Aging BLSA, an ongoing prospective open cohort study. Study participants consisted of non-Hispanic white adults residing in Baltimore city, with one or more visits at age ≥50 years, and complete data n 609–617. Repeated assessments on waist circumference WC and waist:hip ratio WHR were available. Multiple linear mixed models were used to estimate mid-follow-up age central adiposity level and annual rate of change with cut-points set at the sex-specific 80th percentile. The four binary outcomes were: ‘elevated central adiposity’ ECA-WC and ECA-WHR and ‘significant increase in central adiposity’ SICA-WC and SICA-WHR. SNP for VDR four SNP: 1 rs11568820 CdX-2:T-C; 2 rs1544410 BsmI:G-A; 3 rs7975232 ApaI:A-C; 4 rs731236 TaqI:G-A and Megalin three SNP: 1 rs3755166:G-A; 2 rs2075252:C-T; 3 rs4668123:C-T genes were selected. SNP latent classes SNPLC and SNP haplotypes SNPHAP were created. Multiple logistic regression analyses indicated that, in men, higher ECA-WHR odds were associated with SNPLC Megalin2:rs3755166–-rs2075252TT-rs4668123T– v. Megalin1:rs3755166–-rs2075252CC-rs4668123– OR 2·87; 95 % CI 1·15, 7·12; P = 0·023 and that SNPLC Megalin3:rs3755166–-rs2075252CT-rs4668123– v. Megalin1 was linked to lower SICA-WC odds OR 0·48; 95 % CI 0·26, 0·88; P = 0·019 P  0·05 for sex × SNPLC. In women, VDR3 SNPHAP GAA:bAT was related to lower odds of ECA-WC OR 0·37; 95 % CI 0·16, 0·87; P = 0·023 P  0·05 for sex × SNPHAP. Vitamin D-related gene polymorphisms were associated with central adiposity status and change. Future mechanistic studies are needed to confirm those polymorphisms biological significance to central adiposity.



Author: Beydoun, May A.; Tanaka, Toshiko; Beydoun, Hind A.; Ding, Eric L.; Ferrucci, Luigi; Zonderman, Alan B.

Source: https://archive.org/



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