Vol 5: Vitamin E Isoforms as Modulators of Lung Inflammation.Report as inadecuate



 Vol 5: Vitamin E Isoforms as Modulators of Lung Inflammation.


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This article is from Nutrients, volume 5.AbstractAsthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Clinical studies suggest a number of protective dietary factors for asthma, including vitamin E. However, studies of vitamin E in allergy commonly result in seemingly conflicting outcomes. Recent work indicates that allergic inflammation is inhibited by supplementation with the purified natural vitamin E isoform α-tocopherol but elevated by the isoform γ-tocopherol when administered at physiological tissue concentrations. In this review, we discuss opposing regulatory effects of α-tocopherol and γ-tocopherol on allergic lung inflammation in clinical trials and in animal studies. A better understanding of the differential regulation of inflammation by isoforms of vitamin E provides a basis towards the design of clinical studies and diets that would effectively modulate inflammatory pathways in lung disease.



Author: Abdala-Valencia, Hiam; Berdnikovs, Sergejs; Cook-Mills, Joan M.

Source: https://archive.org/



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