Vol 3: Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance.Report as inadecuate



 Vol 3: Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance.


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This article is from Oncoimmunology, volume 3.AbstractThree studies addressed the role of cyclooxygenase-2 COX-2 in mammary tumorigenesis using epithelial and macrophage COX-2 knockout mice. Deletion of COX-2 in either cell restored, at least partially, tumor immunosurveillance either by changing macrophage function to offset pro-tumor effects, or by attracting more cytotoxic T lymphocytes and natural killer cells to the tumor. These studies suggest benefits from targeted COX-2 selective inhibition in combination with immunotherapies.



Author: Markosyan, Nune; Chen, Edward P; Smyth, Emer M

Source: https://archive.org/







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