Vol 27: The Attenuation of Pain Behavior and Serum COX-2 Concentration by Curcumin in a Rat Model of Neuropathic Pain.Report as inadecuate



 Vol 27: The Attenuation of Pain Behavior and Serum COX-2 Concentration by Curcumin in a Rat Model of Neuropathic Pain.


Vol 27: The Attenuation of Pain Behavior and Serum COX-2 Concentration by Curcumin in a Rat Model of Neuropathic Pain. - Download this document for free, or read online. Document in PDF available to download.

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This article is from The Korean Journal of Pain, volume 27.AbstractBackground: Neuropathic pain is generally defined as a chronic pain state resulting from peripheral and-or central nerve injury. There is a lack of effective treatment for neuropathic pain, which may possibly be related to poor understanding of pathological mechanisms at the molecular level. Curcumin, a therapeutic herbal extract, has shown to be effectively capable of reducing chronic pain induced by peripheral administration of inflammatory agents such as formalin. In this study, we aimed to show the effect of curcumin on pain behavior and serum COX-2 level in a Chronic Constriction Injury CCI model of neuropathic pain. Methods: Wistar male rats 150-200 g, n = 8 were divided into three groups: CCI vehicle-treated, sham-operated, and CCI drug-treated group. Curcumin 12.5, 25, 50 mg-kg, IP was injected 24 h before surgery and continued daily for 7 days post-surgery. Behavioral tests were performed once before and following the days 1, 3, 5, 7 after surgery. The serum COX-2 level was measured on day 7 after the surgery. Results: Curcumin 50 mg-kg decreased mechanical and cold allodynia P 0.001 and produced a decline in serum COX-2 level P 0.001. Conclusions: A considerable decline in pain behavior and serum COX-2 levels was seen in rat following administration of curcumin in CCI model of neuropathic pain. High concentration of Curcumin was able to reduce the chronic neuropathic pain induced by CCI model and the serum level of COX-2.



Author: Moini Zanjani, Taraneh; Ameli, Haleh; Labibi, Farzaneh; Sedaghat, Katayoun; Sabetkasaei, Masoumeh

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