Vol 12: The importance of the one carbon cycle nutritional support in human male fertility: a preliminary clinical report.Report as inadecuate



 Vol 12: The importance of the one carbon cycle nutritional support in human male fertility: a preliminary clinical report.


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This article is from Reproductive Biology and Endocrinology : RB&E, volume 12.AbstractBackground: Sperm chromatin structure is often impaired; mainly due to oxidative damage. Antioxidant treatments do not consistently produce fertility improvements and, when given at high doses, they might block essential oxidative processes such as chromatin compaction. This study was intended to assess the effect on male sub-fertility of a pure one carbon cycle nutritional support without strong antioxidants. Methods: Male partners of couples resistant to at least 2 assisted reproductive technology ART attempts, with no evidence of organic causes of infertility and with either DNA fragmentation index DFI measured by Terminal deoxynucleotidyl transferase dUTP Nick End Labeling TUNEL or nuclear decondensation index SDI measured by aniline blue staining exceeding 20%, were invited to take part in a trial of a nutritional support in preparation for a further ART attempt. The treatment consisted of a combination of B vitamins, zinc, a proprietary opuntia fig extract and small amounts of N-acetyl-cysteine and Vitamin E Condensyl™, all effectors of the one carbon cycle. Results: 84 patients were enrolled, they took 1 or 2 Condensyl™ tablets per day for 2 to 12 months. Positive response rates were 64.3% for SDI, 71.4% for DFI and 47.6% for both SDI and DFI. Eighteen couples 21% experienced a spontaneous pregnancy before the planned ART cycle, all ended with a live birth. The remaining 66 couples underwent a new ART attempt 4 IUI; 18 IVF; 44 ICSI resulting in 22 further clinical pregnancies and 15 live births. The clinical pregnancy rate CPR and the live birth rate LBR were 47.6% and 39.3% respectively. The full responders, i.e. the 40 patients achieving an improvement of both SDI and DFI, reported a CPR of 70% and a LBR of 57.5% p 



Author: Dattilo, Maurizio; Cornet, Dominique; Amar, Edouard; Cohen, Marc; Menezo, Yves

Source: https://archive.org/



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