Vol 67: The dose effect of ephedrine on the onset time and intubating conditions after cisatracurium administration.Report as inadecuate



 Vol 67: The dose effect of ephedrine on the onset time and intubating conditions after cisatracurium administration.


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This article is from Korean Journal of Anesthesiology, volume 67.AbstractBackground: The aim of this randomized, double-blind, placebo-controlled study was to evaluate dose effects of ephedrine pretreatment on the onset time and intubating conditions after cisatracurium administration. Methods: A total of 140 adult patients were randomized into 4 groups to receive either 30 µg-kg ephedrine Group 30, n = 35, 70 µg-kg ephedrine Group 70, n = 35, 110 µg-kg ephedrine Group 110, n = 35, 3 ml normal saline Group C, n = 35 as pretreatment given 30 s before anesthetic induction. Neuromuscular block was achieved with 0.15 mg-kg cisatracurium, evaluated accelomyographically with train-of-four stimulation. An anesthesiologist blinded to patient grouping assessed the intubating conditions 1.5 min after cisatracurium administration. Results: An onset time of 70 s was obtained in the ephedrine groups Group 30: 155.4 ± 44.7 s, Group 70: 152.6 ± 40.3 s, Group 110: 151.2 ± 51.6 s compared to Group C 224.6 ± 56.9 s after 0.15 mg-kg of cisatracurium P 0.001. Ephedrine doses of either 70 or 110 µg-kg for pretreatment significantly improved intubating conditions P 0.05. Systolic and diastolic blood pressure and heart rate at 1 min after tracheal intubation were significantly increased than other times in all groups P 0.001, with no differences among the groups. However, 5 patients in Group 110 experienced marked hypertension systolic-diastolic blood pressure: 200-100 mmHg 1 min after tracheal intubation with no patients in other groups. Conclusions: We conclude that pre-treatment with ephedrine 70 µg-kg improved intubating conditions 1.5 min after cisatracurium administration and facilitated the onset of neuromuscular block 70 s without adverse hemodynamic effects.



Author: Cha, Dong Guk; Kim, Kyo Sang; Jeong, Ji Seon; Kwon, Hye Mee

Source: https://archive.org/







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