Vol 1: Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.Report as inadecuate



 Vol 1: Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.


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This article is from Iucrj, volume 1.AbstractHuman carbonic anhydrases are zinc metalloenzymes that catalyze the hydration and dehydration of CO2 and HCO3−, respectively. X-ray crystal structures of a variant of human carbonic anhydrase II in complex with four imidazole derivatives imidazole, 1-methylimidazole, 2-methylimidazole and 4-methylimidazole have been determined in order to identify the binding sites for such compounds, and a mechanism to explain the effects on catalytic activity is proposed.



Author: Aggarwal, Mayank; Kondeti, Bhargav; Tu, Chingkuang; Maupin, C. Mark; Silverman, David N.; McKenna, Robert

Source: https://archive.org/



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