Vol 13: Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin PDOX to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity.Report as inadecuate



 Vol 13: Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin PDOX to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity.


Vol 13: Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin PDOX to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity. - Download this document for free, or read online. Document in PDF available to download.

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This article is from Molecular Cancer, volume 13.AbstractBackground: This work aimed to synthesize a cathepsin B CTSB-cleavable tumor-targeting prodrug peptide doxorubicin PDOX and study the in vivo efficacy and toxicities on an animal model of gastric peritoneal carcinomatosis PC. Methods: PDOX was synthesized using doxorubicin DOX attaching to a CTSB-cleavable dipeptide Ac-Phe-Lys and a para-amino-benzyloxycarbonyl PABC spacer. PC model was established by injecting VX2 tumor cells into the gastric sub-mucosa of 40 rabbits, which then were randomized into 4 groups: the Control n = 10 without treatment, the HIPEC n = 10 receiving cytoreductive surgery CRS plus hyperthermic intraperitoneal chemotherapy HIPEC, the PDOX n = 10 and the DOX n = 10 receiving systemic chemotherapy with PDOX 50.0 mg-kg or DOX 5.0 mg-kg, respectively, after CRS + HIPEC. Results: The median overall survivals OS were 23.0 d 95% CI: 19.9 d - 26.1 d in the Control, 41.0 d 36.9 d - 45.1 d in the HIPEC, 65.0 d 44.1 d - 71.9 d in the PDOX, and 58.0 d 39.6 d - 54.4 d in the DOX. Compared with the Control, the OS was extended by 70% in the HIPEC p 



Author: Tang, Li; Duan, Rui; Zhong, Yan-jun; Firestone, Raymond A; Hong, Ya-ping; Li, Ji-guo; Xin, Yan-chao; Wu, Han-lin; Li, Yan

Source: https://archive.org/



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