Vol 4: Substitution Pattern Reverses the Fluorescence Response of Coumarin Glycoligands upon Coordination with Silver I.Report as inadecuate



 Vol 4: Substitution Pattern Reverses the Fluorescence Response of Coumarin Glycoligands upon Coordination with Silver I.


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This article is from Scientific Reports, volume 4.AbstractDevelopment of sugar-based fluorescence FL chemo-probes is of much interest since sugars are biocompatible, water-soluble and structurally rigid natural starting materials. We report here that fluorescent glycoligands with two triazolyl coumarin moieties installed onto the different positions of an identical glucosyl nucleus exert completely reversed optical response to a metal ion. C3,4-, C2,3- and C4,6-di-substituted coumarin glucosides synthesized by a click reaction similarly showed a selective FL variation in the presence of silver I among a range of metal cations in an aqueous solution. However, the variation was determined to be converse: the FL of the C3,4-ligand was quenched whereas that of the C2,3-C4,6-ligand tangibly enhanced. FL and NMR titrations suggested that this divergence was due to the distinct complexation modes of the conformationally constrained ligands with the ion. The optimal motifs of the ligand-ion complexation were predicted by a computational simulation. Finally, the C2,3-ligand was determined to be of low cytotoxicity and applicable in the FL imaging of silver ions internalized by live cells.



Author: Shi, De-Tai; Wei, Xiao-Li; Sheng, Yayun; Zang, Yi; He, Xiao-Peng; Xie, Juan; Liu, Guixia; Tang, Yun; Li, Jia; Chen, Guo-Rong

Source: https://archive.org/



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