Vol 14: Serum concentration of alpha-1 antitrypsin is significantly higher in colorectal cancer patients than in healthy controls.Report as inadecuate



 Vol 14: Serum concentration of alpha-1 antitrypsin is significantly higher in colorectal cancer patients than in healthy controls.


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This article is from BMC Cancer, volume 14.AbstractBackground: The association between alpha-1 antitrypsin AAT deficiency and colorectal cancer CRC is currently controversial. The present study compares AAT serum concentrations and gene frequencies between a group of CRC patients and a control group of healthy unrelated people HUP. Methods: 267 CRC subjects 63% males, 72 ± 10 years old were enlisted from a Hospital Clinic setting in Asturias, Spain. The HUP group comprised 327 subjects 67% males, mean age 70 ± 7.5 years old from the same geographical region. Outcome measures were AAT serum concentrations measured by nephelometry, and AAT phenotyping characterization by isoelectric focusing. Results: Significantly higher serum concentrations were found among CRC 208 ± 60 than in HUP individuals 144 ± 20.5 p = 0.0001. No differences were found in the phenotypic distribution of the Pi*S and Pi*Z allelic frequencies p = 0.639, although the frequency of Pi*Z was higher in CRC 21% than in HUP subjects 15%. Conclusions: The only statistically significant finding in this study was the markedly higher AAT serum concentrations found in CRC subjects compared with HUP controls, irrespective of whether their Pi* phenotype was normal Pi*MM or deficient Pi*MS, Pi*MZ and Pi*SZ. Although there was a trend towards the more deficient Pi* phenotype the more advanced the tumor, the results were inconclusive due to the small sample size. Consequently, more powerful studies are needed to reach firmer conclusions on this matter.



Author: Perez-Holanda, Sergio; Blanco, Ignacio; Menendez, Manuel; Rodrigo, Luis

Source: https://archive.org/







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