Vol 17: Randomized controlled trials in pediatric critical care: a scoping review.Report as inadecuate



 Vol 17: Randomized controlled trials in pediatric critical care: a scoping review.


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This article is from Critical Care, volume 17.AbstractIntroduction: Evidence from randomized controlled trials RCTs is required to guide treatment of critically ill children, but the number of RCTs available is limited and the publications are often difficult to find. The objectives of this review were to systematically identify RCTs in pediatric critical care and describe their methods and reporting. Methods: We searched MEDLINE, EMBASE, LILACS and CENTRAL from inception to April 16, 2013 and reference lists of included RCTs and relevant systematic reviews. We included published RCTs administering any intervention to children in a pediatric ICU. We excluded trials conducted in neonatal ICUs, those enrolling exclusively preterm infants, and individual patient crossover trials. Pairs of reviewers independently screened studies for eligibility, assessed risk of bias, and abstracted data. Discrepancies were resolved by consensus. Results: We included 248 RCTs: 45 18% were multicentered and 14 6% were multinational. Trials most frequently enrolled both medical and surgical patients 43% but postoperative cardiac surgery was the single largest population studied 19%. The most frequently evaluated types of intervention were medications 63%, devices 11% and nutrition 8%. Laboratory or physiological measurements were the most frequent type of primary outcomes 18%. Half of these trials 50% reported blinding. Of the 107 43% trials that reported an a priori sample size, 34 32% were stopped early. The median number of children randomized per trial was 49 and ranged from 6 to 4,947. The frequency of RCT publications increased at a mean rate of 0.7 RCTs per year P



Author: Duffett, Mark; Choong, Karen; Hartling, Lisa; Menon, Kusum; Thabane, Lehana; Cook, Deborah J

Source: https://archive.org/







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