Vol 15: Relationship between CTX-II and patient characteristics, patient-reported outcome, muscle strength, and rehabilitation in patients with a focal cartilage lesion of the knee: a prospective exploratory cohort study of 48 pReport as inadecuate



 Vol 15: Relationship between CTX-II and patient characteristics, patient-reported outcome, muscle strength, and rehabilitation in patients with a focal cartilage lesion of the knee: a prospective exploratory cohort study of 48 p


Vol 15: Relationship between CTX-II and patient characteristics, patient-reported outcome, muscle strength, and rehabilitation in patients with a focal cartilage lesion of the knee: a prospective exploratory cohort study of 48 p - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 15: Relationship between CTX-II and patient characteristics, patient-reported outcome, muscle strength, and rehabilitation in patients with a focal cartilage lesion of the knee: a prospective exploratory cohort study of 48 p
This article is from BMC Musculoskeletal Disorders, volume 15.AbstractBackground: C-telopeptide fragments of type II collagen CTX-II are created during articular cartilage breakdown and CTX-II is considered useful as a biomarker of osteoarthritis. The primary objective of the present study was to explore the relationship between urinary CTX-II concentration and patient characteristics, patient-reported outcome, muscle strength, and rehabilitation in patients with isolated focal knee cartilage lesions. Furthermore, the secondary objective was to examine differences in urinary CTX-II concentration between patients with focal cartilage lesions and healthy controls. Methods: 48 patients mean age 33.4 years, standard deviation 9.0 with a focal full-thickness International Cartilage Repair Society grade 3 or 4 cartilage lesion on the medial or lateral femoral condyle were included. After baseline assessments, the patients completed a 3-month rehabilitation program and 44 patients attended the 3 month follow-up. Baseline and follow-up assessments consisted of urinary CTX-II, the Knee Injury and Osteoarthritis Outcome Score KOOS, and isokinetic quadriceps and hamstring muscle strength measurements. CTX-II was also analysed in urine samples from 6 healthy individuals, serving as normal controls. Correlations were classified as very weak correlation coefficient r  0.80. Results: Except for age and quadriceps strength, no significant correlations were found between CTX-II concentrations and baseline characteristics, KOOS, or muscle strength. Except for age, all correlations were considered as weak or very weak. The patients with a focal cartilage lesion had significantly higher mean CTX-II concentration than the healthy control individuals both at baseline p = 0.001 and at follow-up p = 0.001. The mean CTX-II concentration tended to decrease during rehabilitation, but the reduction was not significant p = 0.076. Conclusions: The current exploratory study demonstrated that patients with a focal cartilage lesion of the knee had higher concentrations of urinary CTX-II than healthy individuals. In addition, CTX-II concentration tended to decrease during rehabilitation. Trial registration: ClinicalTrials.gov NCT00885729



Author: R?tterud, Jan Harald; Reinholt, Finn P; Beckstr?m, Karen Johanne; Risberg, May Arna; Ar?en, Asbj?rn

Source: https://archive.org/







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