Vol 9: Radiosynthesis and Biological Evaluation of N-18FLabeled Glutamic Acid as a Tumor Metabolic Imaging Tracer.Report as inadecuate



 Vol 9: Radiosynthesis and Biological Evaluation of N-18FLabeled Glutamic Acid as a Tumor Metabolic Imaging Tracer.


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This article is from PLoS ONE, volume 9.AbstractWe have previously reported that N-2-18Ffluoropropionyl-L-methionine 18FFPMET selectively accumulates in tumors. However, due to the poor pharmacokinetics of 18FFPMET in vivo, the potential clinical translation of this observation is hampered. In this study, we rationally designed and synthesized 18F or 11Clabeled N-position L-glutamic acid analogues for tumor imaging. N-2-18Ffluoropropionyl-L-glutamic acid 18FFPGLU was synthesized with a 30±10% n = 10, decay-corrected overall radiochemical yield and a specific activity of 40±25 GBq-μmol n = 10 after 130 min of radiosynthesis. In vitro cell experiments showed that 18FFPGLU was primarily transported through the XAG– system and was not incorporated into protein. 18FFPGLU was stable in urine, tumor tissues, and blood. We were able to use 18FFPGLU in PET imaging and obtained high tumor to background ratios when visualizing tumors tissues in animal models.



Author: Hu, Kongzhen; Du, Kan; Tang, Ganghua; Yao, Shaobo; Wang, Hongliang; Liang, Xiang; Yao, Baoguo; Huang, Tingting; Zang, Linquan

Source: https://archive.org/



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