Vol 9: Relationship of Glycated Hemoglobin Levels with Myocardial Injury following Elective Percutaneous Coronary Intervention in Patients with Type 2 Diabetes Mellitus.Report as inadecuate



 Vol 9: Relationship of Glycated Hemoglobin Levels with Myocardial Injury following Elective Percutaneous Coronary Intervention in Patients with Type 2 Diabetes Mellitus.


Vol 9: Relationship of Glycated Hemoglobin Levels with Myocardial Injury following Elective Percutaneous Coronary Intervention in Patients with Type 2 Diabetes Mellitus. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 9: Relationship of Glycated Hemoglobin Levels with Myocardial Injury following Elective Percutaneous Coronary Intervention in Patients with Type 2 Diabetes Mellitus.
This article is from PLoS ONE, volume 9.AbstractBackground: Glycated hemoglobin HbA1c predicts clinical cardiovascular disease or cardiovascular mortality. However, the relationship between HbA1c and myocardial injury following elective percutaneous coronary intervention PCI in patients with type 2 diabetes mellitus DM has not been investigated. Objectives: The study sought to assess the relationship between HbA1c and myocardial injury following elective PCI in patients with type 2 DM. Methods: We studied a cohort of consecutive 994 diabetic patients with coronary artery disease CAD undergoing elective PCI. Periprocedural myocardial injury was evaluated by analysis of troponin I cTnI. The association between preprocedural HbA1c levels and the peak values of cTnI within 24 hours after PCI was evaluated. Results: Peak postprocedural cTnI 1×upper limit of normal ULN, 3×ULN and 5×ULN were detected in 543 54.6%, 337 33.9% and 245 24.6% respectively. In the multivariate model, higher HbA1c levels were associated with less risk of postprocedural cTnI 1×ULN odds ratio OR, 0.85; 95% confidence interval CI, 0.76–0.95; P = 0.005. There was a trend that higher HbA1c levels were associated with less risk of postprocedural cTnI 3×ULN OR, 0.90; 95% CI, 0.81–1.02; P = 0.088. HbA1c was not associated with the risk of postprocedural cTnI elevation above 5×ULN OR, 0.95; 95% CI, 0.84–1.08; P = 0.411. Conclusions: The present study provided the first line of evidence that higher preprocedural HbA1c levels were associated with less risk of myocardial injury following elective PCI in diabetic patients.



Author: Li, Xiao-Lin; Li, Jian-Jun; Guo, Yuan-Lin; Zhu, Cheng-Gang; Xu, Rui-Xia; Li, Sha; Qing, Ping; Wu, Na-Qiong; Jiang, Li-Xin; Xu, Bo; Gao, Run-Lin

Source: https://archive.org/







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