Vol 8: Prophylactic effect of aqueous extract of Sesamum indicum seeds on ethanol-induced toxicity in male rats.Report as inadecuate



 Vol 8: Prophylactic effect of aqueous extract of Sesamum indicum seeds on ethanol-induced toxicity in male rats.


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This article is from Nutrition Research and Practice, volume 8.AbstractThe liver is vulnerable to alcohol-related injury because it is the primary site of alcohol metabolism. Additionally, a number of potentially dangerous by-products are generated as alcohol is broken down in the liver. However, dietary supplements may prevent or relieve some of alcohols deleterious effects. Therefore, this study was conducted to evaluate the prophylactic effect of aqueous extract of Sesamum indicum SI on ethanol induced toxicity in rats. Male Wistar albino rats were divided into control, ethanol, pre-treatment, simultaneous and post-treatment groups. In the prophylactic experiment, Sesamum indicum, 200 mg-kg body weight was administered by oral gavage for 28 days; two hours before, simultaneously with or two hours after ethanol exposure. Toxicity was induced by administering 45% ethanol 4.8 g-kg bw by oral gavage. Lipid peroxidation TBARS and reduced glutathione GSH levels and catalase CAT, glutathione peroxidase GPx, superoxide dismutase SOD and gluthathione-S-transferase GST activities were then determined in the liver, serum triglyceride TG levels, alanine aminotransferase ALT and aspartate aminotransferase AST activities were monitored and histological examination was carried out. The results revealed that ethanol administration led to significant elevation of TBARS level while depleting in the level of GSH as well as CAT, GPx, SOD and GST activities. Similarly, TG level and ALT and AST activities were elevated. The SI pre-treated group significantly inhibited TBARS, restored GSH level, enhanced CAT, GPx, SOD and GST activities and significantly decreased the elevated level of serum TG, ALT and AST activities. SI treatment simultaneously with ethanol exhibited similar effects to those of the SI pre-treated groups, while the SI post-treated group did not show the same protection as the Pre-treated group. S. indicum possesses antioxidant and hepatoprotective properties, that eliminate the deleterious effects of toxic metabolites of ethanol.



Author: Oyinloye, B.E.; Nwozo, S.O.; Amah, G.H.; Awoyinka, A.O.; Ojo, O.A; Ajiboye, B.O.; Tijani, H.A.

Source: https://archive.org/







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