Vol 9: Protective Effects of Crocin on Ischemia-reperfusion Induced Oxidative Stress in Comparison With Vitamin E in Isolated Rat Hearts.Report as inadecuate



 Vol 9: Protective Effects of Crocin on Ischemia-reperfusion Induced Oxidative Stress in Comparison With Vitamin E in Isolated Rat Hearts.


Vol 9: Protective Effects of Crocin on Ischemia-reperfusion Induced Oxidative Stress in Comparison With Vitamin E in Isolated Rat Hearts. - Download this document for free, or read online. Document in PDF available to download.

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This article is from Jundishapur Journal of Natural Pharmaceutical Products, volume 9.AbstractBackground:: Myocardial Injury caused by ischemia-reperfusion leads to cardiac dysfunction, tissue injury and metabolic changes. The production of reactive oxygen species ROS and lipid peroxidation are accompanied by ischemia-reperfusion injury. Objectives:: The aim of this study was to assess the cardio protective potential effects of crocin in comparison with vitamin E on antioxidant capacity in ischemia-reperfusion of isolated rat hearts. Materials and Methods:: Seventy male Sprague-Dawley rats were randomly divided into seven groups, including: sham, control and experimental groups treated with different doses of crocin 10, 20 and 40 mg-kg or vitamin E 100 mg-kg and a combination of crocin 40 mg-kg with vitamin E 100 mg-kg that were administrated orally for 21 days. The heart was quickly excised, transferred to a Langendorff apparatus at constant pressure and subjected to 30 minutes of global ischemia followed by 60 minutes of reperfusion. Cardiac damage markers and antioxidant enzymes were measured. Results:: The results showed that superoxide dismutase and catalase enzyme activities increased and Mallon de aldehyde MDA decreased in animals pretreated by crocin 40 mg-kg and vitamin E 100 mg-kg. Moreover, there was a significant improvement in post ischemic recovery of antioxidant capacity during reperfusion in rats receiving a combination of crocin 40 mg-kg and vitamin E 100 mg-kg. Conclusions:: The results demonstrated the protective role of crocin on antioxidant capacity, which may partially be related to stability or amplification of antioxidant systems. Like vitamin E, crocin may be beneficial for prevention or treatment of cardiac dysfunction and myocardial infarction in patients with ischemic heart disease.



Author: Dianat, Mahin; Esmaeilizadeh, Mahdi; Badavi, Mohammad; Samarbaf-zadeh, Ali Reza; Naghizadeh, Bahareh

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