Vol 14: Phenolic contents, antioxidant and anticholinesterase potentials of crude extract, subsequent fractions and crude saponins from Polygonum hydropiper L.Report as inadecuate



 Vol 14: Phenolic contents, antioxidant and anticholinesterase potentials of crude extract, subsequent fractions and crude saponins from Polygonum hydropiper L.


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This article is from BMC Complementary and Alternative Medicine, volume 14.AbstractBackground: We investigated Polygonum hydropiper L. P. hydropiper for phenolic contents, antioxidant, anticholinesterase activities, in an attempt to rationalize its use in neurological disorders. Methods: Plant crude extract Ph.Cr, its subsequent fractions: n-hexane Ph.Hex, chloroform Ph.Chf, ethyl acetate Ph.EtAc, n-Butanol Ph.Bt, aqueous Ph.Aq and saponins Ph.Sp were evaluated for 1,1-diphenyl,2-picrylhydrazyl DPPH, 2,2-azinobis3-ethylbenzthiazoline-6-sulfonic acid ABTS free radical scavenging potential. Further, acetylcholinesterase AChE & butyrylcholinesterase BChE inhibitory activities were performed using Ellmans assay. Moreover, total phenolic contents of plant extracts were determined and expressed in mg of gallic acid equivalent per gram of dry sample mg GAE-g dry weight. Results: Among different fractions, Ph.Cr 90.82, Ph.Chf 178.16, Ph.EtAc 203.44 and Ph.Bt 153.61 exhibited high phenolic contents. All fractions showed concentration dependent DPPH scavenging activity, with Ph.EtAc 71.33% IC50 15 μg-ml, Ph.Bt 71.40% IC50 3 μg-ml and Ph.Sp 71.40% IC50 35 μg-ml were most potent. The plant extracts exhibited high ABTS scavenging ability i.e. Ph.Bt 91.03%, Ph.EtAc 90.56%, Ph.Sp 90.84%, Ph.Aq 90.56% with IC50 



Author: Ayaz, Muhammad; Junaid, Muhammad; Ahmed, Jawad; Ullah, Farhat; Sadiq, Abdul; Ahmad, Sajjad; Imran, Muhammad

Source: https://archive.org/



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