Vol 15: Possible Prognostic and Therapeutic Significance of c-Kit Expression, Mast Cell Count and Microvessel Density in Renal Cell Carcinoma.Report as inadecuate



 Vol 15: Possible Prognostic and Therapeutic Significance of c-Kit Expression, Mast Cell Count and Microvessel Density in Renal Cell Carcinoma.


Vol 15: Possible Prognostic and Therapeutic Significance of c-Kit Expression, Mast Cell Count and Microvessel Density in Renal Cell Carcinoma. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 15: Possible Prognostic and Therapeutic Significance of c-Kit Expression, Mast Cell Count and Microvessel Density in Renal Cell Carcinoma.
This article is from International Journal of Molecular Sciences, volume 15.AbstractRenal cell carcinoma RCC is the most frequent renal tumor and its incidence is increasing worldwide. Tumor angiogenesis is known to play a crucial role in the etiopathogenesis of RCC and over the last few years an even deeper knowledge of its contribution in metastatic RCC development has led to the development of numerous molecular targeting agents such as sunitinib, sorafenib, pazopanib, axitinib, tivozanib, and dovitinib. The above agents are principally directed against vascular endothelial growth factor receptor VEGFR members and also against c-Kit receptor c-KitR. The role of c-kitR inhibition on clear cell RCC ccRCC, the main RCC subtype, is less well established. Whether c-kitR activation through its ligand, stem cell factor SCF contributes significantly to the effects of tyrosine kinase inhibitors TKIs treatment remains to be established. It is important to underscore that the c-KitR is expressed on mast cells MCs and cancer cells. After an examination of the c-KitR-SCF pathway, we review here the principal studies that have evaluated c-Kit expression in RCC. Moreover, we summarize some investigations that have observed the distribution of MCs in primary renal cancer and in adjacent normal tissue with appropriate histological immunohistochemical techniques. We also focus on few studies that have evaluated the correlation between RCC proliferation, MC count and microvessel density MVD, as hallmarks of tumor angiogenesis. Thus, the aim of this review of the literature is to clarify if c-KitR expression, MC count and MVD could have prognostic significance and the possible predictive therapeutic implications in RCC.



Author: Marech, Ilaria; Gadaleta, Cosmo Damiano; Ranieri, Girolamo

Source: https://archive.org/







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