Vol 4: Phosphodiesterase type 5 inhibitors for the treatment of post-nerve sparing radical prostatectomy erectile dysfunction in men.Report as inadecuate



 Vol 4: Phosphodiesterase type 5 inhibitors for the treatment of post-nerve sparing radical prostatectomy erectile dysfunction in men.


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This article is from Scientific Reports, volume 4.AbstractProstate cancer PCa is the most common solid neoplasm diagnosed in developed countries. Nerve-sparing radical prostatectomy NS-RP has been widely accepted as the best choice treatment for localised PCa. However, erectile dysfunction ED and urinary incontinence are commonly observed after NS-RP. Using meta-analysis, we examined if phosphodiesterase type 5 inhibitors PDE5-Is could improve the symptoms of ED in patients undergoing NS-RP. This review contained seven randomised placebo-controlled trials with a total of 2,655 male patients. Patients in PDE5-Is group showed significant improvement in the International Index of Erectile Function-Erectile Function domain score IIEF-EF, Global Assessment Questionnaire GAQ, Sexual Encounter Profile question 2 SEP-2 and SEP-3. Although the incidence of treatment-emergent adverse events TEAEs were high in both groups 56.44% vs. 40.63%, the safety profile were acceptable, with low incidence of discontinuation rate due to adverse events. Therefore, PDE5-Is are recommended for the treatment of post-NS-RP ED. Patients should be informed of possible adverse events.



Author: Li, Jinhong; Shi, Qingquan; Pu, Chunxiao; Tang, Yin; Bai, Yunjin; Yuan, Haichao; Li, Xiang; Dong, Qiang; Wei, Qiang; Yuan, Jiuhong; Han, Ping

Source: https://archive.org/







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