Vol 8: Preventive effect of insect tea against reserpine-induced gastric ulcers in mice.Report as inadecuate



 Vol 8: Preventive effect of insect tea against reserpine-induced gastric ulcers in mice.


Vol 8: Preventive effect of insect tea against reserpine-induced gastric ulcers in mice. - Download this document for free, or read online. Document in PDF available to download.

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This article is from Experimental and Therapeutic Medicine, volume 8.AbstractThe aim of the present study was to determine the preventive effect of insect tea against reserpine-induced gastric ulcers in ICR mice. A high 800 mg-kg dose of insect tea reduced the serum levels of the proinflammatory cytokines interleukin IL-6, IL-12, tumor necrosis factor TNF-α and interferon IFN-γ compared with those in mice treated with a low 400 mg-kg dose and the control mice. The serum levels of somatostatin SS and vasoactive intestinal peptide VIP in mice treated with insect tea were higher compared with those in the control mice; however, the serum levels of motilin MOT and substance P SP were lower in mice treated with insect tea than in the control mice. Gastric ulcer inhibitory rate of the insect tea treatment group of mice were much lower compared to the control mice, and the high concentration treated mice were similar to the ranitidine treated mice. The activities of superoxide dismutase SOD and glutathione peroxidase GSH-Px in mice treated with insect tea were higher compared with those in control mice, and similar to those in normal mice and ranitidine-treated mice. The nitric oxide NO and maleic dialdehyde MDA levels of mice treated with a high concentration of insect tea compared with the normal group were close. Using quantitative polymerase chain reaction qPCR assays, the present study revealed that insect tea significantly induced inflammation in the tissues of mice by downregulating the expression of nuclear factor κ-light-chain-enhancer of activated B cells NF-κB, inducible nitric oxide synthase iNOS and cyclooxygenase COX-2, and upregulating the expression of nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor α IκB-α. These results suggest that insect tea is as effective at preventing gastric ulcers as the gastric ulcer drug, ranitidine and it can be used as medicine.



Author: ZHOU, YA-LIN; WANG, RUI; FENG, XIA; ZHAO, XIN

Source: https://archive.org/







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