Vol 44: Pentraxin 3 Is Highly Specific for Predicting Anatomical Complexity of Coronary Artery Stenosis as Determined by the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery Score.Report as inadecuate



 Vol 44: Pentraxin 3 Is Highly Specific for Predicting Anatomical Complexity of Coronary Artery Stenosis as Determined by the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery Score.


Vol 44: Pentraxin 3 Is Highly Specific for Predicting Anatomical Complexity of Coronary Artery Stenosis as Determined by the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery Score. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 44: Pentraxin 3 Is Highly Specific for Predicting Anatomical Complexity of Coronary Artery Stenosis as Determined by the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery Score.
This article is from Korean Circulation Journal, volume 44.AbstractBackground and Objectives: The aim of this study was to examine the hypothesis that pentraxin 3 PTX3 can have a diagnostic value for predicting anatomical complexity of coronary artery stenosis as measured by the Synergy between PCI with Taxus and Cardiac Surgery SYNTAX score. Subjects and Methods: We investigated the association of systemic arterial PTX3 with SYNTAX score among 500 patients with ischemic heart disease assigned to medical treatment 251, percutaneous coronary intervention PCI 197, or coronary artery bypass graft CABG 52. Results: The clinical judgment of the cardiologists was near-perfectly concordant with the SYNTAX score. Mean {99% confidence intervals CIs} SYNTAX scores were 5.8 5.1-6.6, 18.4 17.1-19.8, and 33.2 32.8-33.6 in patients assigned to medical therapy, PCI, and CABG, respectively. The AROC 95% CIs for discriminating between patients with and without a high SYNTAX score 23 was 0.920 0.895-0.946 for systemic arterial levels of PTX3. As the systemic arterial level of PTX3 increased, the SYNTAX scores also increased almost in a curvilinear fashion, with the value corresponding to the SYNTAX score of 23 being 0.29 ng · dL-1. This cutpoint achieved a sensitivity of 0.66 0.57-0.74, a specificity of 0.94 0.91-0.96, a positive predictive value of 0.79 0.70-0.87, and a negative predictive value of 0.89 0.85-0.92. Conclusion: We observed that systemic arterial levels of PTX3 were associated with the SYNTAX score in a curvilinear fashion. The discriminatory power of systemic arterial levels of PTX3 for a high SYNTAX score was excellent. The interesting finding of this study was the near perfect concordance between the decisions made by the cardiologists based on their clinical judgment and the SYNTAX score. The systemic arterial PTX3 level of 0.29 ng · dL-1 was highly specific for diagnosing complex coronary artery stenosis.



Author: Namazi, Mohammad Hasan; Saadat, Habibollah; Safi, Morteza; Vakili, Hossein; Alipourparsa, Saeed; Bozorgmanesh, Mohammadreza; Haybar, Habib

Source: https://archive.org/



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