Vol 29: Optimal Time of Initiating Adjuvant Chemotherapy After Curative Surgery in Colorectal Cancer Patients.Report as inadecuate



 Vol 29: Optimal Time of Initiating Adjuvant Chemotherapy After Curative Surgery in Colorectal Cancer Patients.


Vol 29: Optimal Time of Initiating Adjuvant Chemotherapy After Curative Surgery in Colorectal Cancer Patients. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 29: Optimal Time of Initiating Adjuvant Chemotherapy After Curative Surgery in Colorectal Cancer Patients.
This article is from Annals of Coloproctology, volume 29.AbstractPurpose: Adjuvant chemotherapy is routinely recommended for locally advanced colorectal cancer CRC. There are very few data for the optimal starting date of adjuvant chemotherapy after the surgery. This study aimed to evaluate the effectiveness of earlier adoption of adjuvant chemotherapy after curative surgery for stage III CRC. Methods: In this study, 159 patients with stage III CRC, who had undergone a curative resection, were enrolled retrospectively. Patients were categorized into 3 groups representing different timings to initiate the chemotherapy; less than 2 weeks group 1, 3 to 4 weeks group 2, and more than 5 weeks group 3. The overall survival rate OS and the relapse-free survival rate RFS were analyzed to evaluate the effectiveness of adjuvant chemotherapy. Results: The 5-year OSs of the patients were 73.7% in group 1, 67.0% in group 2, and 55.2% in group 3. The 5-year RFSs of the patients were 48.8% in group 1, 64.7% in group 2, and 57.1% in group 3. There were no significant differences in either the OS or the RFS P = 0.200, P = 0.405. Conclusion: Starting chemotherapy earlier than 6 weeks after surgery does not show any significant difference. Thus, although adjuvant chemotherapy should preferably begin within 6 weeks, the starting date should not necessarily be hastened, and the patients general condition should be taken into consideration.



Author: Kang, Kyu Min; Hong, Kyung Sook; Noh, Gyoung Tae; Oh, Bo-Young; Chung, Soon Sup; Lee, Ryung-Ah; Kim, Kwang Ho

Source: https://archive.org/







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