Vol 6: Overexpression of MEKK2 is associated with colorectal carcinogenesis.Report as inadecuate



 Vol 6: Overexpression of MEKK2 is associated with colorectal carcinogenesis.


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This article is from Oncology Letters, volume 6.AbstractMitogen-activated protein kinase kinase kinase 2 MEKK2 is an important upstream mediator of the extracellular signal-regulated kinase 5 signaling cascade that is essential for a number of cellular functions, including mitogenesis, differentiation and oncogenic transformation. Using western blotting to examine MEKK2 expression in 16 cases of primary colorectal cancer CRC lesions with paired normal mucosa, it was identified that MEKK2 is highly expressed in CRC lesions compared with that of the normal mucosa. Immunohistochemistry of 24 normal mucosa, 24 adenoma and 96 adenocarcinoma colorectal specimens indicated that the expression of MEKK2 was significantly increased in the adenoma and carcinoma specimens compared with that of the normal mucosa cases P0.05. The present study demonstrated that MEKK2 functions as a promotive factor in CRC.



Author: JIANG, LI; HUANG, MEIJIN; WANG, LEI; FAN, XINJUAN; WANG, PUNING; WANG, DAOHAI; FU, XINHUI; WANG, JIANPING

Source: https://archive.org/







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