Vol 101: Observations from the IMPROVE trial concerning the clinical care of patients with ruptured abdominal aortic aneurysm.Report as inadecuate



 Vol 101: Observations from the IMPROVE trial concerning the clinical care of patients with ruptured abdominal aortic aneurysm.


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This article is from The British Journal of Surgery, volume 101.AbstractBackground: Single-centre series of the management of patients with ruptured abdominal aortic aneurysm AAA are usually too small to identify clinical factors that could improve patient outcomes. Methods: IMPROVE is a pragmatic, multicentre randomized clinical trial in which eligible patients with a clinical diagnosis of ruptured aneurysm were allocated to a strategy of endovascular aneurysm repair EVAR or to open repair. The influences of time and manner of hospital presentation, fluid volume status, type of anaesthesia, type of endovascular repair and time to aneurysm repair on 30-day mortality were investigated according to a prespecified plan, for the subgroup of patients with a proven diagnosis of ruptured or symptomatic AAA. Adjustment was made for potential confounding factors. Results: Some 558 of 613 randomized patients had a symptomatic or ruptured aneurysm: diagnostic accuracy was 91·0 per cent. Patients randomized outside routine working hours had higher operative mortality adjusted odds ratio OR 1·47, 95 per cent confidence interval 1·00 to 2·17. Mortality rates after primary and secondary presentation were similar. Lowest systolic blood pressure was strongly and independently associated with 30-day mortality 51 per cent among those with pressure below 70 mmHg. Patients who received EVAR under local anaesthesia alone had greatly reduced 30-day mortality compared with those who had general anaesthesia adjusted OR 0·27, 0·10 to 0·70. Conclusion: These findings suggest that the outcome of ruptured AAA might be improved by wider use of local anaesthesia for EVAR and that a minimum blood pressure of 70 mmHg is too low a threshold for permissive hypotension.



Author: Vol 9: Observer Bias: An Interaction of Temperament Traits with Biases in the Semantic Perception of Lexical Material.

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