Vol 14: Mitogen activated protein kinase kinase kinase 3 MAP3K3-MEKK3 overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis.Report as inadecuate



 Vol 14: Mitogen activated protein kinase kinase kinase 3 MAP3K3-MEKK3 overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis.


Vol 14: Mitogen activated protein kinase kinase kinase 3 MAP3K3-MEKK3 overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 14: Mitogen activated protein kinase kinase kinase 3 MAP3K3-MEKK3 overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis.
This article is from BMC Cancer, volume 14.AbstractBackground: Mitogen-activated protein kinase kinase kinase3 MAP3K3-MEKK3 was identified to be differentially expressed in esophageal squamous cell carcinoma ESCC using cDNA microarrays by our laboratory. Here in we determined the clinical significance of MEKK3 in ESCC. Methods: Immunohistochemical analysis of MEKK3 expression was carried out in archived tissue sections from 93 ESCCs, 47 histologically normal and 61 dysplastic esophageal tissues and correlated with clinicopathological parameters and disease prognosis over up to 7.5 years for ESCC patients. Results: MEKK3 expression was significantly increased in esophageal dysplasia and ESCC in comparison with normal mucosa ptrend 



Author: Hasan, Raghibul; Sharma, Rinu; Saraya, Anoop; Chattopadhyay, Tushar K; DattaGupta, Siddartha; Walfish, Paul G; Chauhan, Shyam S; Ralhan, Ranju

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