Vol 9: Long-Term Outcomes and Complications of Trabeculectomy for Secondary Glaucoma in Patients with Familial Amyloidotic Polyneuropathy.Report as inadecuate



 Vol 9: Long-Term Outcomes and Complications of Trabeculectomy for Secondary Glaucoma in Patients with Familial Amyloidotic Polyneuropathy.


Vol 9: Long-Term Outcomes and Complications of Trabeculectomy for Secondary Glaucoma in Patients with Familial Amyloidotic Polyneuropathy. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 9: Long-Term Outcomes and Complications of Trabeculectomy for Secondary Glaucoma in Patients with Familial Amyloidotic Polyneuropathy.
This article is from PLoS ONE, volume 9.AbstractObjective: Secondary glaucoma is a serious complication in patients with transthyretin TTR-related familial amyloidotic polyneuropathy FAP. We assessed the long-term outcomes and complications of trabeculectomy with mitomycin C MMC for secondary glaucoma associated with FAP. Methods: Medical case records of Kumamoto University Hospital were retrospectively reviewed. Twenty-one eyes of 13 patients 10 with FAP ATTR Val30Met; 3 with FAP ATTR Tyr114Cys underwent trabeculectomy with MMC and follow-up of at least 2 years. The primary outcome measure was Kaplan-Meier survival, with failure of this treatment being defined as an intraocular pressure IOP of ≤5 mm Hg or ≥22 mm Hg on two consecutive visits or as additional operations needed to reduce IOP. Secondary outcome measures included complications, bleb characteristics, and additional postoperative interventions required. Results: The mean postoperative follow-up period was 5.7 years range, 2.2–12.7 years. Kaplan-Meier analysis indicated probabilities of success of 0.76, 0.67, and 0.53 at 1, 2, and 3 years after operation, respectively. Significant complications included ocular decompression retinopathy in 7 eyes 33% and bleb encapsulation in 10 eyes 48%. Twelve eyes 57% needed additional surgery, such as bleb revision or trabeculectomy with MMC, to reduce IOP. Conclusions: Trabeculectomy with MMC may not be optimal for patients with FAP-related glaucoma and may have several significant complications.



Author: Kawaji, Takahiro; Inoue, Toshihiro; Hara, Ryuhei; Eiki, Daisuke; Ando, Yukio; Tanihara, Hidenobu

Source: https://archive.org/







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