Vol 9: Leukocyte Mitochondrial DNA Copy Number in Blood Is Not Associated with Major Depressive Disorder in Young Adults.Report as inadecuate



 Vol 9: Leukocyte Mitochondrial DNA Copy Number in Blood Is Not Associated with Major Depressive Disorder in Young Adults.


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This article is from PLoS ONE, volume 9.AbstractBackground: Major depressive disorder MDD is the leading cause of disability worldwide, and has significant genetic predisposition. Mitochondria may have a role in MDD and so mitochondrial DNA mtDNA has been suggested as a possible biomarker for this disease. We aimed to test whether the mtDNA copy number of peripheral blood leukocytes is related to MDD in young adults. Methods: A case-control study was conducted with 210 MDD patients and 217 healthy controls HC. The mtDNA copy number was measured by quantitative polymerase chain reaction qPCR method. Depression severity was assessed by the Hamilton-17 Depression Rating Scale HDRS-17. Results: We found no significant differences in mtDNA copy number between MDD patients and HC, though the power analysis showed that our sample size has enough power to detect the difference. There were also no significant correlations between mtDNA copy number and the clinical characteristics such as age, age of onset, episodes, Hamilton Depression Rating Scale HDRS score and Global Assessment of Function Scale GAF score in MDD patients. Conclusion: Our study suggests that leukocyte mtDNA copy number is unlikely to contribute to MDD, but it doesn’t mean that we can exclude the possibility of involvement of mitochondria in the disease. Further studies are required to elucidate whether mtDNA can be a biomarker of MDD.



Author: He, Ying; Tang, Jinsong; Li, Zongchang; Li, Hong; Liao, Yanhui; Tang, Yanqing; Tan, Liwen; Chen, Jindong; Xia, Kun; Chen, Xiaogang

Source: https://archive.org/



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