Vol 8: Ligand-gated ion channel interacting proteins and their role in neuroprotection.Report as inadecuate



 Vol 8: Ligand-gated ion channel interacting proteins and their role in neuroprotection.


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This article is from Frontiers in Cellular Neuroscience, volume 8.AbstractIon channel receptors are a vital component of nervous system signaling, allowing rapid and direct conversion of a chemical neurotransmitter message to an electrical current. In recent decades, it has become apparent that ionotropic receptors are regulated by protein-protein interactions with other ion channels, G-protein coupled receptors and intracellular proteins. These other proteins can also be modulated by these interactions with ion channel receptors. This bidirectional functional cross-talk is important for critical cellular functions such as excitotoxicity in pathological and disease states like stroke, and for the basic dynamics of activity-dependent synaptic plasticity. Protein interactions with ion channel receptors can therefore increase the computational capacity of neuronal signaling cascades and also represent a novel target for therapeutic intervention in neuropsychiatric disease. This review will highlight some examples of ion channel receptor interactions and their potential clinical utility for neuroprotection.



Author: Li, Shupeng; Wong, Albert H. C.; Liu, Fang

Source: https://archive.org/







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